Article
Protecting genomic integrity in somatic cells and embryonic stem cells.
Mutation research - 3 Jan 2007
Hong Y, Cervantes R B, Tichy E, Tischfield J A, Stambrook P J
Abstract excerpt
Mutation frequencies at some loci in mammalian somatic cells in vivo approach 10(-4). The majority of these events occur as a consequence of loss of heterozygosity (LOH) due to mitotic recombination. Such high levels of DNA damage in somatic cells, which can accumulate with age, will cause injury and, after a latency period, may lead to somatic disease and ultimately death. This high level of DNA damage is...
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