Article
Apolipoprotein E genotype and its effect on duration and severity of early and late onset Alzheimer's disease.
The British journal of psychiatry : the journal of mental science - 1 Oct 1995
Norrman J, Brookes A J, Yates C, St Clair D
Abstract excerpt
BACKGROUND: The apolipoprotein E (ApoE) epsilon 4 allele is associated with an increased risk of senile and probably presenile Alzheimer's disease. It is not yet clear whether the epsilon 4 allele also influences the duration/rate of progress of illness and the severity of the dementia. METHOD: W...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Brain
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Middle Aged
- Prognosis