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Article

Apolipoprotein E epsilon4 allele is unrelated to cognitive or functional decline in Alzheimer's disease: retrospective and prospective analysis.

Dementia and geriatric cognitive disorders - 1 Jan 2006

Kleiman Timothy, Zdanys Kristina, Black Benjamin, Rightmer Tracy, Grey Monique, Garman Katherine, Macavoy Martha, Gelernter Joel, van Dyck Christopher

Abstract excerpt

OBJECTIVE: The apolipoprotein E (ApoE) epsilon4 allele is a well-documented genetic risk factor for Alzheimer's disease (AD). Its role, if any, in the progression of cognitive and functional impairment in AD has been the subject of discrepant reports in the literature. This study aimed to determine whether ApoE epsilon4 dose is related to the progression of cognitive and functional decline in AD patients by...

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Identifiers

PMID: 16699282
DOI: 10.1159/000093316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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