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Article

Apolipoprotein E genotype and progression of Alzheimer's disease: the Rotterdam Study.

Journal of neurology - 1 Apr 1999

Slooter A J, Houwing-Duistermaat J J, van Harskamp F, Cruts M, Van Broeckhoven C, Breteler M M, Hofman A, Stijnen T, van Duijn C M

Abstract excerpt

The APOE*4 allele of the apolipoprotein E gene increases the risk of Alzheimer's disease (AD), but whether it also affects the course of the disease is controversial. However, all studies on this issue until now have been based on patients at various stages of disease. In the present population-based study, 97 patients were included at a similar stage, i.e., before the onset of symptoms, and followed for up to 5...

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Source

Identifiers

PMID: 10367700
DOI: 10.1007/s004150050351

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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