Article
Epidemiological, clinical, and neuropathological study of apolipoprotein E genotype in Alzheimer's disease.
Annals of the New York Academy of Sciences - 16 Dec 1996
Hyman B T, Gomez-Isla T, Rebeck G W, Briggs M, Chung H, West H L, Greenberg S, Mui S, Nichols S, Wallace R, Growdon J H
Abstract excerpt
Our studies of the APOE genotype in AD confirm a strong association of the epsilon 4 allele with development of AD and a decreased risk associated with epsilon 2. From a clinical/neuropathological perspective, the major effects of APOE epsilon 4 are to lower the age of onset and to increase the amount of A beta deposit in the brain. Neither rate of progression nor number of neurofibrillary tangles were affected....
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