The role of APOE polymorphisms in late-onset dementias.

doi:10.1007/s000180050223

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Article

The role of APOE polymorphisms in late-onset dementias.

Cellular and molecular life sciences : CMLS - 1 Sept 1998

Corder E H, Lannfelt L, Bogdanovic N, Fratiglioni L, Mori H

Abstract excerpt

Epidemiologic and laboratory results consistently implicate the APOE gene in the pathogenesis of late-onset Alzheimer's disease (AD): the epsilon 4 allele increases risk in a dose-dependent fashion, while epsilon 2 confers protection. Individuals are susceptible for AD in varying degrees dependin...

Topics

Age of Onset
Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Amyloid beta-Protein Precursor
Animals
Apolipoproteins E
Brain
Dementia
Genotype
Humans
Mice
Mice, Transgenic
Models, Biological
Neurofibrillary Tangles
Polymorphism, Genetic
Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 9791536
DOI: 10.1007/s000180050223
PMCID: PMC11147178

Genes

APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9791536-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

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Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.