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Article

The role of APOE polymorphisms in late-onset dementias.

Cellular and molecular life sciences : CMLS - 1 Sept 1998

Corder E H, Lannfelt L, Bogdanovic N, Fratiglioni L, Mori H

Abstract excerpt

Epidemiologic and laboratory results consistently implicate the APOE gene in the pathogenesis of late-onset Alzheimer's disease (AD): the epsilon 4 allele increases risk in a dose-dependent fashion, while epsilon 2 confers protection. Individuals are susceptible for AD in varying degrees depending on which combination of APOE alleles has been inherited, APOE promoter polymorphism and other factors. Deposition of...

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Source

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Identifiers

PMID: 9791536
DOI: 10.1007/s000180050223
PMCID: PMC11147178

Genes

APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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