Article
[The apolipoprotein E-epsilon 4 allele is a risk factor for Alzheimer disease with early and late onset].
Der Nervenarzt - 1 Nov 1994
Kurz A, Lautenschlager N, Haupt M, Zimmer R, von Thülen B, Altland K, Lauter H, Müller U
Abstract excerpt
The apolipoprotein E genotype was determined in 50 patients with clinically diagnosed and prospectively confirmed Alzheimer's disease of mild to moderate severity and in 50 healthy age- and sex-matched controls. The frequency of the epsilon 4 allele was increased in the patients irrespective of the age at onset and of a possible familial transmission of the disease. It was associated with a relative risk of 2.97....
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Female
- Gene Frequency
- Genetic Markers
- Genotype
- Humans