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Article

Apolipoprotein E isoforms and the development of low and high Braak stages of Alzheimer's disease-related lesions.

Acta neuropathologica - 1 Sept 1999

Ohm T G, Scharnagl H, März W, Bohl J

Abstract excerpt

In recent research, apolipoprotein-E (apoE) polymorphism has been shown to influence the formation of neurofibrillary changes and the accumulation of beta/A4-amyloid, the histopathological hallmarks of Alzheimer's disease (AD). Clinical studies associate the apoE allele epsilon4 with earlier onset of the disease, although the clinical speed of progression remains unchanged. Time course estimates have also...

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Identifiers

PMID: 10483785
DOI: 10.1007/s004010051080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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