Article
Clinical and neuropathological correlates of apolipoprotein E genotype in Alzheimer's disease. Window on molecular epidemiology.
Annals of the New York Academy of Sciences - 17 Jan 1996
Hyman B T, Gomez-Isla T, West H, Briggs M, Chung H, Growdon J H, Rebeck G W
Abstract excerpt
Inheritance of the apolipoprotein E (apo E) epsilon 4 allele has recently been found to be associated with Alzheimer's disease. We have studied the clinical and neuropathological correlates of apolipoprotein E genotype in a large group of Alzheimer's patients. The primary influence on clinical presentation is a shift towards earlier age of onset in individuals who have the apo E epsilon 4 gene: no change in...
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