Article
Apolipoprotein E genotype in the prediction of cognitive decline and dementia in a prospectively studied elderly population.
Dementia (Basel, Switzerland) - 1 Jan 2000
Brayne C, Harrington C R, Wischik C M, Huppert F A, Chi L Y, Xuereb J H, O'Connor D W, Paykel E S
Abstract excerpt
An increased apolipoprotein E (ApoE) type epsilon 4 allele frequency is associated with both sporadic and familial late-onset Alzheimer's disease (AD). The age of onset of disease in patients homozygous for the epsilon 4 allele appears to be decreased by approximately 15 years compared with E2/3 individuals. In order to assess the influence of this allele on both dementia and cognitive decline in the elderly we...
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