Apolipoprotein E genotype in the prediction of cognitive decline and dementia in a prospectively studied elderly population.

doi:10.1159/000106873

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Article

Apolipoprotein E genotype in the prediction of cognitive decline and dementia in a prospectively studied elderly population.

Dementia (Basel, Switzerland) - 1 Jan 2000

Brayne C, Harrington C R, Wischik C M, Huppert F A, Chi L Y, Xuereb J H, O'Connor D W, Paykel E S

Abstract excerpt

An increased apolipoprotein E (ApoE) type epsilon 4 allele frequency is associated with both sporadic and familial late-onset Alzheimer's disease (AD). The age of onset of disease in patients homozygous for the epsilon 4 allele appears to be decreased by approximately 15 years compared with E2/3...

Topics

Aged
Aging
Alleles
Alzheimer Disease
Apolipoproteins E
Cognition
Cognition Disorders
Dementia
Female
Forecasting
Genotype
Humans
Male
Prospective Studies

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