Article
Apolipoprotein E genotype and rate of decline in probable Alzheimer's disease.
Archives of neurology - 1 Apr 1996
Dal Forno G, Rasmusson D X, Brandt J, Carson K A, Brookmeyer R, Troncoso J, Kawas C H
Abstract excerpt
BACKGROUND: The risk of Alzheimer's disease (AD) appears to increase, and the age at onset to decrease, with the number of epsilon 4 alleles. If this relationship is due to increased rate of pathophysiological change, the presence of epsilon 4 would be expected to influence progression of disease, predicting a more rapid decline with increasing number of epsilon 4 alleles. OBJECTIVE: To determine if the frequency...
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