Article
Somatic mutations are frequent and increase with age in human kidney epithelial cells.
Human molecular genetics - 1 Feb 1996
Martin G M, Ogburn C E, Colgin L M, Gown A M, Edland S D, Monnat R J
Abstract excerpt
We have used a primary cloning assay to determine the frequency of 6-thioguanine (TG)-resistant tubular epithelial cells in kidney tissue from 72 human donors ranging in age from 2 to 94 years. The frequency of TG-resistant mutants ranged from approximately 5 x 10(-5) for donors in the first decade of life to approximately 2.5 x 10(-4) for donors in the eighth and later decades of life. Two different statistical...
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