Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans.

doi:10.1016/0921-8734(95)00018-2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans.

Mutation research - 1 Oct 1995

Jones I M, Thomas C B, Tucker B, Thompson C L, Pleshanov P, Vorobtsova I, Moore D H

Abstract excerpt

Analysis of two human populations for dependence of somatic mutation on age has revealed both similarities and differences. The studies performed employed peripheral blood lymphocytes and measured the efficiency with which these cells form clones in vitro (cloning efficiency, CE) and the frequency of cells with inactivating mutations of the hypoxanthine phosphoribosyltransferase gene (mutant frequency, MF). The...

Topics

Adult
Aging
Anticoagulants
Citrates
Citric Acid
Clone Cells
Environmental Exposure
Female
Glucose
Heparin
Humans
Hypoxanthine Phosphoribosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation

Radiation Effects

Regression Analysis

Russia

Source

Open in PubMed

Identifiers

PMID: 7565868
DOI: 10.1016/0921-8734(95)00018-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7565868-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans.PMID 7565868Read ↗

Factors affecting HPRT mutant frequency in T-lymphocytes of smokers and nonsmokers.Semantic proximity Read ↗

Reduced proliferation rate of hypoxanthine-phosphoribosyl transferase mutant human T-lymphocytes in vitro.Semantic proximity Read ↗

Studies on the HPRT mutant frequency in T lymphocytes from healthy Indian male population as a function of age and smoking.Semantic proximity Read ↗

Russian mutational spectrum differs from that of their Western counterparts.Semantic proximity Read ↗

Quantification and molecular characterization of hprt mutants of human T-lymphocytes.Semantic proximity Read ↗

A comparison of somatic mutational spectra in healthy study populations from Russia, Sweden and USA.Semantic proximity Read ↗

Hprt mutant frequency and GSTM1 genotype in non-smoking healthy individuals.Semantic proximity Read ↗

Enhanced hprt mutant frequency but no significant difference in mutation spectrum between a smoking and a non-smoking human population.Semantic proximity Read ↗

Influence of smoking and donor age on the spectrum of in vivo mutation at the HPRT-locus in T lymphocytes of healthy adults.Semantic proximity Read ↗

Elevated frequencies of hypoxanthine phosphoribosyltransferase lymphocyte mutants are detected in Russian liquidators 6 to 10 years after exposure to radiation from the Chernobyl nuclear power plant accident.Semantic proximity Read ↗

Influence of sex, smoking and age on human hprt mutation frequencies and spectra.Semantic proximity Read ↗

Methods for detecting somatic mutations in vitro: the human T-cell cloning assay selecting for HPRT mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.