Frequency of HPRT mutant lymphocytes in a human control population as determined by the T-cell cloning procedure.

doi:10.1016/0165-7992(95)00050-x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Frequency of HPRT mutant lymphocytes in a human control population as determined by the T-cell cloning procedure.

Mutation research - 1 Oct 1995

Hüttner E, Holzapfel B, Kropf S

Abstract excerpt

The T-cell-cloning assay was established to determine the frequency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) mutant lymphocytes in the presence of the selective agent 6-thioguanine in peripheral blood from a human control population. We investigated 44 healthy adults (blood donors) and found a mean mutant frequency of 7.2 x 10(-6) (geometric mean 5.6 x 10(-6). An elevated mean mutant frequency...

Topics

Adult
Age Factors
Analysis of Variance
Antimetabolites, Antineoplastic
Cell Line
Clone Cells
Drug Resistance, Neoplasm
Female
Gene Frequency
Humans
Hypoxanthine Phosphoribosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Linear Models

Male

Middle Aged

Mutation

Population Surveillance

Reference Values

Sex Factors

Source

Open in PubMed

Identifiers

PMID: 7477056
DOI: 10.1016/0165-7992(95)00050-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7477056-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequency of HPRT mutant lymphocytes in a human control population as determined by the T-cell cloning procedure.PMID 7477056Read ↗

Studies on the HPRT mutant frequency in T lymphocytes from healthy Indian male population as a function of age and smoking.Semantic proximity Read ↗

Methods for detecting somatic mutations in vitro: the human T-cell cloning assay selecting for HPRT mutants.Semantic proximity Read ↗

Measurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations.Semantic proximity Read ↗

Hprt mutant frequency and GSTM1 genotype in non-smoking healthy individuals.Semantic proximity Read ↗

Enhanced hprt mutant frequency but no significant difference in mutation spectrum between a smoking and a non-smoking human population.Semantic proximity Read ↗

The human T-cell cloning assay: identifying genotypes susceptible to drug toxicity and somatic mutation.Semantic proximity Read ↗

Quantification and molecular characterization of hprt mutants of human T-lymphocytes.Semantic proximity Read ↗

In vitro induction, expression and selection of thioguanine-resistant mutants with human T-lymphocytes.Semantic proximity Read ↗

Factors affecting HPRT mutant frequency in T-lymphocytes of smokers and nonsmokers.Semantic proximity Read ↗

Thioguanine-resistant mutant frequency in T-lymphocytes from a healthy human population.Semantic proximity Read ↗

Determination of hprt mutant frequencies in T-lymphocytes from a healthy pediatric population: statistical comparison between newborn, children and adult mutant frequencies, cloning efficiency and age.Semantic proximity Read ↗

Reduced proliferation rate of hypoxanthine-phosphoribosyl transferase mutant human T-lymphocytes in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.