Article
A mouse kidney cell line with a G:C --> C:G transversion mutator phenotype.
Mutation research - 19 Jun 2002
Shin Chi Y, Ponomareva Olga N, Connolly Lanelle, Turker Mitchell S
Abstract excerpt
We report the identification of a mouse kidney epithelial cell line (K435) in which G:C-->C:G transversion mutations occur at an elevated rate and are the predominant spontaneous events observed at the selectable Aprt locus. Of three genotoxins tested, ultraviolet radiation (UV), ionizing radiation, and hydrogen peroxide, only UV exposure was able to alter the spectrum of small mutational events. To determine if...
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