Article
Novel types of mutation identified at the hprt locus of human T-lymphocytes.
Mutation research - 1 Jul 1994
Hou S M
Abstract excerpt
The T-cell cloning assay detecting mutations at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus provides a well developed system for studying human somatic gene mutation. The hprt mutational spectrum comprises missense, nonsense and splice mutations, as well as large structural alterations including deletions, duplications and insertions. Only few of the hprt deletions, which represent 10-15% of...
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