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Article

The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage.

Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2002

Colgin Lorel M, Hackmann Alden F M, Emond Mary J, Monnat Raymond J

Abstract excerpt

Few data exist on somatic mutation in the epithelial cell lineages that play a central role in human biology and disease. To delineate the "landscape" of somatic mutation in a human epithelial cell lineage, we determined the frequency and molecular nature of somatic mutations occurring in vivo in the X-linked HPRT gene of kidney tubular epithelial cells. Kidney epithelial mutants were frequent (range 0.5 to 4.2 x...

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Identifiers

PMID: 11818556
DOI: 10.1073/pnas.032655699
PMCID: PMC122209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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