Hprt mutant frequency and GSTM1 genotype in non-smoking healthy individuals.

doi:10.1002/em.2850250203

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Article

Hprt mutant frequency and GSTM1 genotype in non-smoking healthy individuals.

Environmental and molecular mutagenesis - 1 Jan 1995

Hou S M, Fält S, Steen A M

Abstract excerpt

The T-cell cloning assay which combines mitogen- and growth factor-dependent expansion of lymphocyte clones with thioguanine selection of hypoxanthine-guanine phosphoribosyl transferase (hprt)-negative cells has been extensively used for studying human somatic gene mutation in vivo. However, large interindividual variations in the hprt mutant frequency (MF), much of which is not explained by donor attributes such...

Topics

Adult
Age Factors
Aged
Base Sequence
Clone Cells
DNA Primers
Gene Deletion
Genetic Variation
Genotype
Glutathione Transferase
Humans
Hypoxanthine Phosphoribosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inactivation, Metabolic

Lymphocytes

Male

Middle Aged

Molecular Sequence Data

Mutagenesis, Site-Directed

Source

Open in PubMed

Identifiers

PMID: 7698112
DOI: 10.1002/em.2850250203

Genes

GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7698112-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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