Article
Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease.
Molecular genetics and metabolism - 1 Jan 2003
Dobrovolsky Vasily N, Bucci Thomas, Heflich Robert H, Desjardins John, Richardson Frank C
Abstract excerpt
The thymidine kinase (Tk) gene codes for a cytosolic protein involved in the pyrimidine nucleotide salvage pathway. A functional Tk gene is not necessary for cells in culture, and a naturally occurring Tk deficient phenotype has not been described in humans or animal models. In order to determine the biological significance of the Tk gene, we created Tk(-/-) knockout (KO) mice through homologous recombination in...
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