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Article

The human T-cell cloning assay: identifying genotypes susceptible to drug toxicity and somatic mutation.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014

Hou Sai-Mei

Abstract excerpt

Humans exhibit marked genetic polymorphisms in drug metabolism that contribute to high incidence of adverse effects in susceptible individuals due to altered balance between metabolic activation and detoxification. The T-cell cloning assay, which detects mutations in the gene for hypoxanthine-guanine phosphoribosyl transferase (HPRT), is the most well-developed reporter system for studying specific locus mutation...

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PMID: 24623236
DOI: 10.1007/978-1-62703-739-6_22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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