Quantification and molecular characterization of hprt mutants of human T-lymphocytes.

Abstract excerpt

Somatic mutations have been implicated as critical early events in carcinogenesis. Point mutations, deletions, and translocation events have been shown to activate oncogenes or inactivate suppressor oncogenes. In human population monitoring, quantitative analysis of mutation events that affect ge...

Topics

• Cells, Cultured
• Chromosome Mapping
• Gene Deletion
• Humans
• Mutation
• T-Lymphocytes