An intramolecular association between the head and tail domains of vinculin modulates talin binding.

Abstract excerpt

Three independent lines of evidence demonstrate an interaction between the head and tail domains of vinculin. First, both the purified 30-kDa tail fragment and a fusion protein containing tail domain, vinculin residues 884-1066, protect purified 95-kDa head domain from cleavage by protease V8 in a specific, dose-dependent manner. Second, direct binding studies between the 95-kDa head and the V884-1066 fusion...

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