Article
An intramolecular association between the head and tail domains of vinculin modulates talin binding.
The Journal of biological chemistry - 29 Apr 1994
Johnson R P, Craig S W
Abstract excerpt
Three independent lines of evidence demonstrate an interaction between the head and tail domains of vinculin. First, both the purified 30-kDa tail fragment and a fusion protein containing tail domain, vinculin residues 884-1066, protect purified 95-kDa head domain from cleavage by protease V8 in...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Chickens
- Cross-Linking Reagents
- Ethyldimethylaminopropyl Carbodiimide
- Glutathione Transferase
- Hydrolysis
- Molecular Sequence Data
- Mutation
- Protein Binding
- Recombinant Fusion Proteins
- Serine Endopeptidases
- Talin
- Vinculin