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Article

The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.

PLoS genetics - 1 Nov 2014

Ellis Stephanie J, Lostchuck Emily, Goult Benjamin T, Bouaouina Mohamed, Fairchild Michael J, López-Ceballos Pablo, Calderwood David A, Tanentzapf Guy

Abstract excerpt

Talin serves an essential function during integrin-mediated adhesion in linking integrins to actin via the intracellular adhesion complex. In addition, the N-terminal head domain of talin regulates the affinity of integrins for their ECM-ligands, a process known as inside-out activation. We previously showed that in Drosophila, mutating the integrin binding site in the talin head domain resulted in weakened...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25393120
DOI: 10.1371/journal.pgen.1004756
PMCID: PMC4230843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.PMID 25393120Read ↗

Distinct developmental roles for direct and indirect talin-mediated linkage to actin.Semantic proximity Read ↗

Multiple factors contribute to integrin-talin interactions in vivo.Semantic proximity Read ↗

The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link.Semantic proximity Read ↗

Talin autoinhibition is required for morphogenesis.Semantic proximity Read ↗

Structural basis of integrin activation by talin.Semantic proximity Read ↗

The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion.Semantic proximity Read ↗

Tensin stabilizes integrin adhesive contacts in Drosophila.Semantic proximity Read ↗

Integrin-independent repression of cadherin transcription by talin during axis formation in Drosophila.Semantic proximity Read ↗

Talin is required to position and expand the luminal domain of the Drosophila heart tube.Semantic proximity Read ↗

Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans.Semantic proximity Read ↗

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The Structure of the talin head reveals a novel extended conformation of the FERM domain.Semantic proximity Read ↗

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