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Article

Mechano-coupling and regulation of contractility by the vinculin tail domain.

Biophysical journal - 15 Jan 2008

Mierke Claudia Tanja, Kollmannsberger Philip, Zitterbart Daniel Paranhos, Smith James, Fabry Ben, Goldmann Wolfgang Heinrich

Abstract excerpt

Vinculin binds to multiple focal adhesion and cytoskeletal proteins and has been implicated in transmitting mechanical forces between the actin cytoskeleton and integrins or cadherins. It remains unclear to what extent the mechano-coupling function of vinculin also involves signaling mechanisms. We report the effect of vinculin and its head and tail domains on force transfer across cell adhesions and the...

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Biomechanical Phenomena
Cell Aggregation
Cell Line, Tumor
Cell Movement
Mechanotransduction, Cellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Tertiary

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Identifiers

PMID: 17890382
DOI: 10.1529/biophysj.107.108472
PMCID: PMC2481521

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Mechano-coupling and regulation of contractility by the vinculin tail domain.PMID 17890382Read ↗

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