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Article

The structure of an interdomain complex that regulates talin activity.

The Journal of biological chemistry - 29 May 2009

Goult Benjamin T, Bate Neil, Anthis Nicholas J, Wegener Kate L, Gingras Alexandre R, Patel Bipin, Barsukov Igor L, Campbell Iain D, Roberts Gordon C K, Critchley David R

Abstract excerpt

Talin is a large flexible rod-shaped protein that activates the integrin family of cell adhesion molecules and couples them to cytoskeletal actin. It exists in both globular and extended conformations, and an intramolecular interaction between the N-terminal F3 FERM subdomain and the C-terminal part of the talin rod contributes to an autoinhibited form of the molecule. Here, we report the solution structure of...

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Identifiers

PMID: 19297334
DOI: 10.1074/jbc.M900078200
PMCID: PMC2685691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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