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Article

Phosphorylation at Y1065 in vinculin mediates actin bundling, cell spreading, and mechanical responses to force.

Biochemistry - 2 Sept 2014

Tolbert Caitlin E, Thompson Peter M, Superfine Richard, Burridge Keith, Campbell Sharon L

Abstract excerpt

Vinculin is an essential structural adaptor protein that localizes to sites of adhesion and is involved in a number of cell processes including adhesion, spreading, motility, force transduction, and cell survival. The C-terminal vinculin tail domain (Vt) contains the necessary structural components to bind and cross-link actin filaments. Actin binding to Vt induces a conformational change that promotes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25115937
DOI: 10.1021/bi500678x
PMCID: PMC4151700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation at Y1065 in vinculin mediates actin bundling, cell spreading, and mechanical responses to force.PMID 25115937Read ↗

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