Article
αE-catenin is an autoinhibited molecule that coactivates vinculin.
Proceedings of the National Academy of Sciences of the United States of America - 29 May 2012
Choi Hee-Jung, Pokutta Sabine, Cadwell Gregory W, Bobkov Andrey A, Bankston Laurie A, Liddington Robert C, Weis William I
Abstract excerpt
αE-catenin, an essential component of the adherens junction, interacts with the classical cadherin-β-catenin complex and with F-actin, but its precise role is unknown. αE-catenin also binds to the F-actin-binding protein vinculin, which also appears to be important in junction assembly. Vinculin and αE-catenin are homologs that contain a series of helical bundle domains, D1-D5. We mapped the vinculin-binding site...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.