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Article

Vinculin regulates assembly of talin: β3 integrin complexes.

Journal of cellular biochemistry - 1 Jun 2014

Nanda Suman Yadav, Hoang Thuy, Patel Priya, Zhang Hao

Abstract excerpt

Vinculin is a talin-binding protein that promotes integrin-mediated cell adhesion, but the mechanisms are not understood. Because talin is a direct activator of integrins, we asked whether and how vinculin regulates the formation of integrin: talin complexes. We report that VD1 (aa 1-258) and its...

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Identifiers

PMID: 24446374
DOI: 10.1002/jcb.24772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24446374-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vinculin regulates assembly of talin: β3 integrin complexes.PMID 24446374Read ↗

Two distinct head-tail interfaces cooperate to suppress activation of vinculin by talin.Semantic proximity Read ↗

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.Semantic proximity Read ↗

Structural basis of integrin activation by talin.Semantic proximity Read ↗

The structure of an interdomain complex that regulates talin activity.Semantic proximity Read ↗

Talin binding to integrin beta tails: a final common step in integrin activation.Semantic proximity Read ↗

Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration.Semantic proximity Read ↗

αE-catenin is an autoinhibited molecule that coactivates vinculin.Semantic proximity Read ↗

Multiple factors contribute to integrin-talin interactions in vivo.Semantic proximity Read ↗

Differential Binding of Active and Inactive Integrin to Talin.Semantic proximity Read ↗

An intramolecular association between the head and tail domains of vinculin modulates talin binding.Semantic proximity Read ↗

The phosphotyrosine binding-like domain of talin activates integrins.Semantic proximity Read ↗

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.Semantic proximity Read ↗

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