Article
Two distinct head-tail interfaces cooperate to suppress activation of vinculin by talin.
The Journal of biological chemistry - 29 Apr 2005
Cohen Daniel M, Chen Hui, Johnson Robert P, Choudhury Begum, Craig Susan W
Abstract excerpt
Vinculin is autoinhibited by an intramolecular interaction that masks binding sites for talin and F-actin. Although a recent structural model explains autoinhibition solely in terms of the interaction between vinculin tail (Vt) and residues 1-258 (D1), we find an absolute requirement for an interface involving the D4 domain of head (Vh residues 710-836) and Vt. Charge-to-alanine mutations in Vt revealed a class...
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