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Article

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.

The EMBO journal - 4 Aug 2004

Papagrigoriou Evangelos, Gingras Alexandre R, Barsukov Igor L, Bate Neil, Fillingham Ian J, Patel Bipin, Frank Ronald, Ziegler Wolfgang H, Roberts Gordon C K, Critchley David R, Emsley Jonas

Abstract excerpt

The interaction between the cytoskeletal proteins talin and vinculin plays a key role in integrin-mediated cell adhesion and migration. We have determined the crystal structures of two domains from the talin rod spanning residues 482-789. Talin 482-655, which contains a vinculin-binding site (VBS), folds into a five-helix bundle whereas talin 656-789 is a four-helix bundle. We show that the VBS is composed of a...

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Identifiers

PMID: 15272303
DOI: 10.1038/sj.emboj.7600285
PMCID: PMC514914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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