Article
A conformational switch in vinculin drives formation and dynamics of a talin-vinculin complex at focal adhesions.
The Journal of biological chemistry - 9 Jun 2006
Cohen Daniel M, Kutscher Brett, Chen Hui, Murphy Douglas B, Craig Susan W
Abstract excerpt
Dynamic interactions between the cytoskeleton and integrins control cell adhesion, but regulatory mechanisms remain largely undefined. Here, we tested the extent to which the autoinhibitory head-tail interaction (HTI) in vinculin regulates formation and lifetime of the talin-vinculin complex, a proposed mediator of integrin-cytoskeleton bonds. In an ectopic recruitment assay, mutational reduction of HTI drove...
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