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Article

Suppression of tumorigenicity of breast cancer cells by microcell-mediated chromosome transfer: studies on chromosomes 6 and 11.

Cancer research - 1 Mar 1994

Negrini M, Sabbioni S, Possati L, Rattan S, Corallini A, Barbanti-Brodano G, Croce C M

Abstract excerpt

Development of breast cancer has been associated with deletions at multiple chromosomal regions, including 6q, 11p, and 11q. In this study we analyzed the effects of the introduction of chromosomes 6 and 11 on the cell phenotype of the breast cancer cell lines MDA-MB-231 and MCF-7. Chromosome 6 induced alterations of in vitro growth properties and suppressed tumorigenicity of MDA-MB-231 cells. Spontaneous...

Topics

Breast Neoplasms
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 6
Female
Gene Transfer Techniques
Genes, Tumor Suppressor
Humans
Neoplasm Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Tumor Cells, Cultured

Source

Identifiers

PMID: 8118824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8118824-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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