Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A human melanoma metastasis-suppressor locus maps to 6q16.3-q23

15 May 2000

Abstract excerpt

Loss, deletion or rearrangement along large portions of the long arm (q-arm) of chromosome 6 occurs in >80% of late-stage human melanomas, suggesting that genes controlling malignant characteristics are encoded there. Metastasis, but not tumorigenicity, was completely suppressed in the human melanoma cell line C8161 into which an additional intact chromosome 6 had been introduced by microcell-mediated chromosome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cutaneous Melanoma Detection and Management
Share to Genomics and Chromatin Dynamics
Share to Melanoma and MAPK Pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10797266
DOI: 10.1002/(sici)1097-0215(20000515)86:4<524::aid-ijc13>3.0.co;2-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A human melanoma metastasis-suppressor locus maps to 6q16.3-q23PMID 10797266Read ↗

Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential displaySemantic proximity Read ↗

KiSS-1, a Novel Human Malignant Melanoma Metastasis-Suppressor GeneSemantic proximity Read ↗

Tumorigenicity in human melanoma cell lines controlled by introduction of human chromosome 6.Semantic proximity Read ↗

Functional evidence of novel tumor suppressor genes for cutaneous malignant melanoma.Semantic proximity Read ↗

Identification of tumor-suppressor genes using human melanoma cell lines UACC903, UACC903(+6), and SRS3 by comparison of expression profiles.Semantic proximity Read ↗

Metastasis-Suppressor Genes: a Review and Perspective on an Emerging FieldSemantic proximity Read ↗

The distal region of the long arm of human chromosome 1 carries tumor suppressor activity for a human fibrosarcoma line.Semantic proximity Read ↗

Deletion mapping suggests that the 1p22 melanoma susceptibility gene is a tumor suppressor localized to a 9-Mb interval.Semantic proximity Read ↗

A cell cycle regulator potentially involved in genesis of many tumor types.Semantic proximity Read ↗

Simple tandem repeat allelic deletions confirm the preferential loss of distal chromosome 6q in melanoma.Semantic proximity Read ↗

A network of clinically and functionally relevant genes is involved in the reversion of the tumorigenic phenotype of MDA-MB-231 breast cancer cells after transfer of human chromosome 8.Semantic proximity Read ↗

Refined localization of the melanoma (MLM) gene on chromosome 9p by analysis of allelic deletions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.