Suppression of tumorigenesis by the breast cancer cell line MCF-7 following transfer of a normal human chromosome 11.

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Article

Suppression of tumorigenesis by the breast cancer cell line MCF-7 following transfer of a normal human chromosome 11.

Oncogene - 1 Oct 1992

Negrini M, Castagnoli A, Sabbioni S, Recanatini E, Giovannini G, Possati L, Stanbridge E J, Nenci I, Barbanti-Brodano G

Abstract excerpt

Breast cancer development is associated with several genetic abnormalities. Loss of heterozygosity in the short arm of chromosome 11 has been observed in 30% of tumors. We found homozygosity at five chromosome 11 polymorphic loci in genomic DNA of the MCF-7 breast carcinoma cell line, suggesting a possible loss of one chromosome 11. We have studied the transformed and tumorigenic phenotypes of MCF-7 cells...

Topics

Animals
Breast Neoplasms
Cell Line
Chromosome Aberrations
Chromosomes, Human, Pair 11
Female
Genes, Tumor Suppressor
Humans
Hybrid Cells
Mammary Neoplasms, Experimental
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Transplantation

Phenotype

Receptors, Estrogen

Transfection

Transplantation, Heterologous

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1408142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1408142-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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