The distal region of the long arm of human chromosome 1 carries tumor suppressor activity for a human fibrosarcoma line.

doi:10.1016/0165-4608(94)90194-5

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Article

The distal region of the long arm of human chromosome 1 carries tumor suppressor activity for a human fibrosarcoma line.

Cancer genetics and cytogenetics - 1 Apr 1994

Klein K G, Bouck N P

Abstract excerpt

Loss or inactivation of tumor suppressor genes has been implicated by indirect methods in the etiology of most human cancers. In the functional studies presented here, tumor suppressors on human chromosome 1 were investigated using microcell-mediated chromosome transfer. Translocated chromosomes...

Topics

Cell Line, Transformed
Chromosomes, Human, Pair 1
Fibrosarcoma
Genes, Tumor Suppressor
Humans
Hybrid Cells
Karyotyping
Neoplasm Transplantation
Phenotype
Tumor Cells, Cultured
X Chromosome

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