Article
A network of clinically and functionally relevant genes is involved in the reversion of the tumorigenic phenotype of MDA-MB-231 breast cancer cells after transfer of human chromosome 8.
Oncogene - 27 Jan 2005
Seitz Susanne, Frege Renate, Jacobsen Anja, Weimer Jörg, Arnold Wolfgang, von Haefen Clarissa, Niederacher Dieter, Schmutzler Rita, Arnold Norbert, Scherneck Siegfried
Abstract excerpt
Several investigations have supposed that tumor suppressor genes might be located on human chromosome 8. We used microcell-mediated transfer of chromosome 8 into MDA-MB-231 breast cancer cells and generated independent hybrids with strongly reduced tumorigenic potential. Loss of the transferred chromosome results in reappearance of the malignant phenotype. Expression analysis identified a set of 109 genes...
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