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Article

Suppression of tumorigenicity of a Wilms' tumor cell line is associated with a decrease in synthesis of two proteins.

Oncogene - 1 Oct 1991

Wheeler T T, Xiao J P, Dowdy S F, Stanbridge E J, Young D A

Abstract excerpt

Wilms' tumor has been associated with deletions in two loci on chromosome 11, and the introduction of a translocated human chromosome [t(X;11)] into a Wilms' tumor cell line (G401.6TG.6) by microcell hybridization suppresses tumor formation in nude mice. The tumorigenic phenotype is restored in segregants of these microcell hybrids, in which the introduced chromosome is lost. We have used ultrahigh-resolution...

Topics

Child, Preschool
Chromosomes, Human, Pair 11
Gene Expression Regulation, Neoplastic
Humans
Kidney Neoplasms
Male
Neoplasm Proteins
Phenotype
Tumor Cells, Cultured
Wilms Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 1656366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1656366-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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