Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transfer of chromosome 8 into two breast cancer cell lines: total exclusion of three regions indicates location of putative in vitro growth suppressor genes.

Cancer genetics and cytogenetics - 1 Jun 2003

Wilson Peter, Cuthbert Andrew, Marsh Anna, Arnold Jeremy, Flanagan James, Mulford Christine, Trott Deborah, Baker Elizabeth, Purdie David, Newbold Robert, Chenevix-Trench Georgia

Abstract excerpt

Loss of heterozygosity (LOH) of the short arm of chromosome 8 occurs frequently in breast tumors. Fine mapping of the smallest regions of overlap of the deletions indicates that multiple tumor suppressor genes may be located in this region. We have performed microcell-mediated chromosome transfer of chromosome 8 into two breast cancer cell lines, 21MT-1 and T-47D. Twenty-two of the resulting hybrids were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cell Division

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Painting

Share to Chromosomes, Human, Pair 8

Share to Hybrid Cells

Share to Karyotyping

Share to Loss of Heterozygosity

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12781443
DOI: 10.1016/s0165-4608(02)00850-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transfer of chromosome 8 into two breast cancer cell lines: total exclusion of three regions indicates location of putative in vitro growth suppressor genes.PMID 12781443Read ↗

Genetic background of different cancer cell lines influences the gene set involved in chromosome 8 mediated breast tumor suppression.Semantic proximity Read ↗

A network of clinically and functionally relevant genes is involved in the reversion of the tumorigenic phenotype of MDA-MB-231 breast cancer cells after transfer of human chromosome 8.Semantic proximity Read ↗

Chromosome 8 genetic analysis and phenotypic characterization of 21 ovarian cancer cell lines.Semantic proximity Read ↗

Complex CGH alterations on chromosome arm 8p at candidate tumor suppressor gene loci in breast cancer cell lines.Semantic proximity Read ↗

Loss of heterozygosity from the short arm of chromosome 8 is an early event in breast cancersSemantic proximity Read ↗

The distal region of the long arm of human chromosome 1 carries tumor suppressor activity for a human fibrosarcoma line.Semantic proximity Read ↗

Suppression of tumorigenicity of breast cancer cells by microcell-mediated chromosome transfer: studies on chromosomes 6 and 11.Semantic proximity Read ↗

Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer.Semantic proximity Read ↗

Mapping of a candidate colorectal cancer tumor-suppressor gene to a 900-kilobase region on the short arm of chromosome 8.Semantic proximity Read ↗

Analysis of the candidate 8p21 tumour suppressor, BNIP3L, in breast and ovarian cancer.Semantic proximity Read ↗

Chromosome region 8p11-p21: Refined mapping and molecular alterations in breast cancerSemantic proximity Read ↗

Evolution of 8p loss in transformed human prostate epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.