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Article

Tumorigenicity in human melanoma cell lines controlled by introduction of human chromosome 6.

Science (New York, N.Y.) - 2 Feb 1990

Trent J M, Stanbridge E J, McBride H L, Meese E U, Casey G, Araujo D E, Witkowski C M, Nagle R B

Abstract excerpt

Chromosome banding analysis of human malignant melanoma has documented the nonrandom alteration of chromosome 6. To determine the relevance of chromosome 6 abnormalities in melanoma, a normal chromosome 6 was directly introduced into melanoma cell lines. The resulting (+6) microcell hybrids were significantly altered in their phenotypic properties in culture and lost their ability to form tumors in nude mice. The...

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Identifiers

PMID: 2300817
DOI: 10.1126/science.2300817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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