Article
Tumorigenicity in human melanoma cell lines controlled by introduction of human chromosome 6.
Science (New York, N.Y.) - 2 Feb 1990
Trent J M, Stanbridge E J, McBride H L, Meese E U, Casey G, Araujo D E, Witkowski C M, Nagle R B
Abstract excerpt
Chromosome banding analysis of human malignant melanoma has documented the nonrandom alteration of chromosome 6. To determine the relevance of chromosome 6 abnormalities in melanoma, a normal chromosome 6 was directly introduced into melanoma cell lines. The resulting (+6) microcell hybrids were...
Topics
- Animals
- Cell Division
- Cell Line
- Chromosome Aberrations
- Chromosome Banding
- Chromosomes, Human, Pair 6
- Humans
- Hybrid Cells
- Karyotyping
- Melanoma
- Mice
- Phenotype