Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 mutations and microsatellite analysis of loss of heterozygosity in malignant gliomas.

Cancer genetics and cytogenetics - 1 Jun 1994

Tenan M, Colombo B M, Pollo B, Cajola L, Broggi G, Finocchiaro G

Abstract excerpt

We have studied alterations of the p53 gene in 27 patients with malignant gliomas. Loss of heterozygosity (LOH) was investigated by microsatellite analysis in 23 patients (22 informative) and detected in nine. Exons 5 through 9 were amplified by polymerase chain reaction (PCR) in these nine patients: alterations were found in five cases (three missense mutations, one non-sense mutation, and one putative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Base Sequence
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Deletion

Share to Genes, p53

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 8019958
DOI: 10.1016/0165-4608(94)90012-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 mutations and microsatellite analysis of loss of heterozygosity in malignant gliomas.PMID 8019958Read ↗

p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency.Semantic proximity Read ↗

Loss of heterozygosity of chromosome 10p in human gliomas.Semantic proximity Read ↗

Loss of heterozygosity on chromosomes 10q, 9p, 17p and 13q in malays with malignant glioma.Semantic proximity Read ↗

Chromosome 22q allelic losses at microsatellite loci in human astrocytic tumors.Semantic proximity Read ↗

Demonstration of p53 protein and TP53 gene mutations in oligodendrogliomas.Semantic proximity Read ↗

Absence of mutation of the p73 gene in astrocytic neoplasms.Semantic proximity Read ↗

Presence of allelic loss and PTEN mutations in malignant gliomas from Malay patients.Semantic proximity Read ↗

Alterations of the TP53 gene in human gliomas.Semantic proximity Read ↗

Instability of microsatellites in human gliomas.Semantic proximity Read ↗

Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer.Semantic proximity Read ↗

Loss of heterozygosity and microsatellite instability at the retinoblastoma locus in osteosarcomas.Semantic proximity Read ↗

p53 allelic imbalance in astrocytoma detected using fluorescent PCR of microsatellite repeat polymorphisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.