p53 mutations and microsatellite analysis of loss of heterozygosity in malignant gliomas.

doi:10.1016/0165-4608(94)90012-4

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Article

p53 mutations and microsatellite analysis of loss of heterozygosity in malignant gliomas.

Cancer genetics and cytogenetics - 1 Jun 1994

Tenan M, Colombo B M, Pollo B, Cajola L, Broggi G, Finocchiaro G

Abstract excerpt

We have studied alterations of the p53 gene in 27 patients with malignant gliomas. Loss of heterozygosity (LOH) was investigated by microsatellite analysis in 23 patients (22 informative) and detected in nine. Exons 5 through 9 were amplified by polymerase chain reaction (PCR) in these nine patie...

Topics

Adult
Aged
Base Sequence
Brain Neoplasms
Chromosome Deletion
Female
Genes, p53
Glioma
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

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