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Article

Loss of heterozygosity and microsatellite instability at the retinoblastoma locus in osteosarcomas.

Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Sept 1996

Belchis D A, Meece C A, Benko F A, Rogan P K, Williams R A, Gocke C D

Abstract excerpt

Studies of osteosarcoma cell lines or frozen tissue have detected loss of heterozygosity (LOH) at the retinoblastoma (RB) locus by Southern blot analysis or restriction fragment length polymorphism. Most archived clinical specimens cannot be analyzed by these techniques. We analyzed formalin-fixed, paraffin-embedded samples from 19 cases of osteosarcoma for molecular changes at the RB locus using polymerase chain...

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Source

Identifiers

PMID: 8866236
DOI: 10.1097/00019606-199609000-00011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of heterozygosity and microsatellite instability at the retinoblastoma locus in osteosarcomas.PMID 8866236Read ↗

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