Article
Absence of mutation of the p73 gene in astrocytic neoplasms.
International journal of oncology - 1 Sept 2001
Alonso M E, Bello M J, Lomas J, Gonzalez-Gomez P, Arjona D, De Campos J M, Gutierrez M, Isla A, Vaquero J, Rey J A
Abstract excerpt
In subgroups of astrocytic neoplasms, including glioblastoma (GBM), mutations of the p53 tumour suppressor gene lead to loss of growth-suppressive properties. A p53-related gene termed p73 has recently been identified; its gene product shows structural and functional similarities to p53. After being mapped to chromosome region 1p36, p73 was proposed to act as a tumour suppressor gene, as this region is frequently...
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