p53 allelic imbalance in astrocytoma detected using fluorescent PCR of microsatellite repeat polymorphisms.

doi:10.1111/j.1365-2990.1995.tb01069.x

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Article

p53 allelic imbalance in astrocytoma detected using fluorescent PCR of microsatellite repeat polymorphisms.

Neuropathology and applied neurobiology - 1 Aug 1995

al-Sarraj S, Bridges L R, Cawkwell L, Lewis F A, Quirke P

Abstract excerpt

Previous reports have shown that p53 gene alteration plays an important role in tumourigenesis. Allelic loss of 17p in astrocytomas was detected in previous studies by restriction fragment length polymorphisms (RFLP). In this study we have analysed 47 cases of astrocytic tumours (26 glioblastomas...

Topics

Alleles
Astrocytoma
Base Sequence
Brain Neoplasms
DNA
Genes, p53
Humans
Microsatellite Repeats
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

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