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Article

p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency.

Cancer research - 15 Mar 1992

Frankel R H, Bayona W, Koslow M, Newcomb E W

Abstract excerpt

Mutations in the p53 gene were analyzed in 40 gliomas using the single strand conformation polymorphism assay together with restriction fragment length polymorphism analysis to assess loss of heterozygosity for 17p alleles in the same tumors. Mutations occurred in 40% of the gliomas and were foun...

Topics

Adolescent
Adult
Aged
Alleles
Amino Acid Sequence
Blotting, Southern
Brain Neoplasms
Child
Chromosomes, Human, Pair 17
Codon
Female
Genes, Retinoblastoma
Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glioma

Heterozygote

Humans

Male

Middle Aged

Source

Identifiers

PMID: 1347252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1347252-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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