Article
p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency.
Cancer research - 15 Mar 1992
Frankel R H, Bayona W, Koslow M, Newcomb E W
Abstract excerpt
Mutations in the p53 gene were analyzed in 40 gliomas using the single strand conformation polymorphism assay together with restriction fragment length polymorphism analysis to assess loss of heterozygosity for 17p alleles in the same tumors. Mutations occurred in 40% of the gliomas and were found in exons 4-8 of the p53 gene. G:C to T:A transversions, which occur in high frequency in some lung (greater than...
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