Article
Alterations of the TP53 gene in human gliomas.
Cancer research - 1 Mar 1994
Rasheed B K, McLendon R E, Herndon J E, Friedman H S, Friedman A H, Bigner D D, Bigner S H
Abstract excerpt
Glial tumors of all grades and histological types from 72 adults and 48 children were analyzed for mutations of the TP53 gene, loss of heterozygosity (LOH) for 17p, and accumulation of TP53 protein to determine whether the incidence and type of TP53 alterations differ among tumors of different hi...
Topics
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Brain Neoplasms
- Child
- Child, Preschool
- Chromosome Aberrations
- Chromosomes, Human, Pair 17
- Female
- Gene Amplification
- Gene Deletion
- Genes, p53
- Glioma
- Heterozygote
- Humans
- Immunohistochemistry