Article
Loss of heterozygosity of chromosome 10p in human gliomas.
Genomics - 1 Jun 1996
Kimmelman A C, Ross D A, Liang B C
Abstract excerpt
Molecular loss of heterozygosity studies on human gliomas have shown several regions on chromosome 10 frequently deleted in higher grade tumors, suggesting that chromosome 10 may contain several tumor suppressor genes. We assessed loss of heterozygosity with microsatellite markers in 20 gliomas, consisting of various grades and containing two chromosome 10 copies. The locus that exhibited the most loss (69%) was...
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