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Article

Mutation of the p53 gene precedes aneuploid clonal divergence in colorectal carcinoma.

British journal of cancer - 1 Feb 1995

Carder P J, Cripps K J, Morris R, Collins S, White S, Bird C C, Wyllie A H

Abstract excerpt

To establish whether p53 mutation precedes or follows clonal divergence in human colorectal carcinomas, 17 tumours were analysed at multiple sites (2-5 each) for single-strand conformation polymorphisms (SSCP) within exons 5-8 of the p53 gene. A previous study had demonstrated subclones of differing DNA ploidy in these tumours, but all showed immunocytochemical evidence for p53 stabilisation, using the monoclonal...

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Identifiers

PMID: 7841032
DOI: 10.1038/bjc.1995.46
PMCID: PMC2033599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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