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Article

Mutation of the p53 gene precedes aneuploid clonal divergence in colorectal carcinoma.

British journal of cancer - 1 Feb 1995

Carder P J, Cripps K J, Morris R, Collins S, White S, Bird C C, Wyllie A H

Abstract excerpt

To establish whether p53 mutation precedes or follows clonal divergence in human colorectal carcinomas, 17 tumours were analysed at multiple sites (2-5 each) for single-strand conformation polymorphisms (SSCP) within exons 5-8 of the p53 gene. A previous study had demonstrated subclones of differing DNA ploidy in these tumours, but all showed immunocytochemical evidence for p53 stabilisation, using the monoclonal...

Topics

Alleles
Aneuploidy
Base Sequence
Carcinoma
Clone Cells
Colorectal Neoplasms
DNA Mutational Analysis
Exons
Genes, p53
Humans
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single-Stranded Conformational

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Open in PubMed Open full text

Identifiers

PMID: 7841032
DOI: 10.1038/bjc.1995.46
PMCID: PMC2033599

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7841032-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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