Article
Stabilised p53 facilitates aneuploid clonal divergence in colorectal cancer.
Oncogene - 1 May 1993
Carder P, Wyllie A H, Purdie C A, Morris R G, White S, Piris J, Bird C C
Abstract excerpt
Mutations in the p53 tumour suppressor gene are amongst the most frequent genetic abnormalities acquired in tumours. Recent studies in vitro suggest that mutant p53 destabilises the genome and facilitates development of aneuploidy. Here, in a study of 83 colorectal carcinomas, we demonstrate that alterations in p53 (detected by immunocytochemical stabilisation) precede and apparently facilitate divergence of...
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