Article
Effect of mutation and conformation on the function of p53 in colorectal cancer.
The Journal of pathology - 1 Aug 2000
Webley K M, Shorthouse A J, Royds J A
Abstract excerpt
In vitro studies have shown that immunoprecipitation with conformation-specific antibodies allows discrimination between different forms of p53; however, the significance of this has not been determined for human tumours. This study therefore examined p53 conformation in colorectal tumours and correlated this with mutational status and evidence of in vivo p53 downstream activity. Moreover, it was shown that for...
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