Article
p53 mutations in colorectal cancers in the patients of Metropolitan New York.
Anticancer research - 1 Jan 2000
van den Broek M H, Jhanwar S C, Fodde R, Chaganti R S, Meera Khan P M
Abstract excerpt
An unselected series of 19 colorectal adenocarcinomas obtained from patients treated by surgery at Memorial Sloan-Kettering Cancer Center (MSKCC), New York, USA was investigated for mutations in exons 5, 6, 7 and 8 of the p53 gene. Ten of the tumors revealed at least one somatic mutation either in the exon 5 or 8. Two of them were found to carry two somatic mutations each. The DGGE pattern of one of these two...
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